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Schisandrin C Ameliorates Learning and Memory Deficits by Aβ 1–42 ‐induced Oxidative Stress and Neurotoxicity in Mice
Author(s) -
Mao Xin,
Liao Zhengzheng,
Guo Lin,
Xu Xuan,
Wu Bo,
Xu Mengjie,
Zhao Xu,
Bi Kaishun,
Jia Ying
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5390
Subject(s) - morris water navigation task , oxidative stress , superoxide dismutase , glutathione peroxidase , pharmacology , hippocampus , neurotoxicity , medicine , glutathione , antioxidant , memory impairment , chemistry , biochemistry , toxicity , cognition , enzyme , psychiatry
Schisandrin C (SCH‐C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize the effect of SCH‐C on memory impairment and further research on pathological changes in Aβ 1–42 ‐induced Alzheimer's disease mice. Mice were administration with SCH‐C daily for 5 days in the lateral cerebral ventricles using sterotaxically implanted cannula. Cognitive functions were assessed by Y‐maze test, active avoidance test and Morris water maze test in all groups, and the level of Aβ 1–42 and neuronal injury induced by Aβ 1–42 were reversed remarkably following SCH‐C treatment compared with sham group; meanwhile the impairment of short‐term or working memory was dramatically improved. In addition, SCH‐C significantly inhibited total cholinesterase (ChEtotal), and increased superoxide dismutase (SOD) and glutathione peroxidase (GSH‐px) activity glutathione (GSH) levels in the hippocampus and cerebral cortex. It can be speculated that SCH‐C offers protection against Aβ 1–42 ‐induced dysfunction in learning and memory by inhibiting ChEtotal and its antioxidant action. Copyright © 2015 John Wiley & Sons, Ltd.