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Hypolipidemic Effect and Mechanism of Palmatine from Coptis chinensis in Hamsters Fed High‐Fat diet
Author(s) -
Ning Na,
He Kai,
Wang Yanzhi,
Zou Zongyao,
Wu Hao,
Li Xuegang,
Ye Xiaoli
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5295
Subject(s) - palmatine , cholesterol 7 alpha hydroxylase , coptis chinensis , ldl receptor , endocrinology , berberine , medicine , hyperlipidemia , triglyceride , cholesterol , excretion , chemistry , pharmacology , biology , lipoprotein , alternative medicine , traditional chinese medicine , pathology , diabetes mellitus
Palmatine (PAL) is one of the main alkaloids in Coptis chinensis . The present aim was to investigate the hypolipidemic effect and mechanism of palmatine in hamsters fed with high‐fat diet (HFD). PAL treatment decreased serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) levels, as well as increased fecal excretion of TC and total bile acids (TBA) in hyperlipidemic hamsters. Furthermore, PAL treatment up‐regulated low‐density lipoprotein receptor (LDLR) and cholesterol 7α‐hydroxylase (CYP7A1) mRNA and protein expression and down‐regulated apical sodium‐dependent bile salt transporter (ASBT) mRNA and protein expression. These results demonstrated that PAL as a potential natural cholesterol lowering agent works by up‐regulating LDLR and CYP7A1 mRNA and protein expression, down‐regulating ASBT mRNA and protein expression, as well as enhancing fecal excretion of TC and TBA. The findings in our study suggest that palmatine could be a potential natural agent for treating hyperlipidemia. Copyright © 2015 John Wiley & Sons, Ltd.