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Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species
Author(s) -
OrbánGyapai Orsolya,
Lajter Ildikó,
Hohmann Judit,
Jakab Gusztáv,
Vasas Andrea
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5275
Subject(s) - polygonaceae , xanthine oxidase , pharmacognosy , traditional medicine , inhibitory postsynaptic potential , chemistry , biology , botany , pharmacology , biochemistry , enzyme , biological activity , medicine , in vitro , endocrinology
The xanthine oxidase (XO) inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera ( Fallopia , Oxyria , Persicaria , Polygonum and Rumex ) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro . From different plant parts (aerial parts, leaves, flowers, fruits and roots), a total of 196 extracts were prepared by subsequent extraction with methanol and hot H 2 O and solvent–solvent partition of the MeOH extract yielding n ‐hexane, chloroform and 50% MeOH subextracts. It was found that the chloroform subextracts and/or the remaining 50% MeOH extracts of Fallopia species ( F. bohemica , F. japonica and F. sachalinensis ), Rumex species ( R. acetosa , R. acetosella , R. alpinus , R. conglomeratus , R. crispus , R. hydrolapathus , R. pulcher , R. stenophyllus , R. thyrsiflorus , R. obtusifolius subsp. subalpinus , R. patientia ) and Polygonum bistorta , Polygonum hydropiper , Polygonum lapathifolium and Polygonum viviparum demonstrated the highest XO inhibitory activity (>85% inhibition) at 400 µg/mL. The IC 50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella , are considered worthy of activity‐guided phytochemical investigations. Copyright © 2014 John Wiley & Sons, Ltd.