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Anti‐Leishmanial, Anti‐Inflammatory and Antimicrobial Activities of Phenolic Derivatives from Tibouchina paratropica
Author(s) -
Tracanna María I.,
Fortuna Antonio M.,
Contreras Cárdenas Angel V.,
Marr Alexandra K.,
McMaster W. Robert,
GómezVelasco Anaximandro,
SánchezArreola Eugenio,
Hernández Luis Ricardo,
Bach Horacio
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5263
Subject(s) - antimicrobial , anti inflammatory , leishmania donovani , lipopolysaccharide , macrophage , chemistry , ic50 , microbiology and biotechnology , cytokine , leishmania major , traditional medicine , leishmania , pharmacology , biology , in vitro , biochemistry , immunology , medicine , leishmaniasis , parasite hosting , visceral leishmaniasis , world wide web , computer science
A new phenolic derivative, 2,8‐dihydroxy‐7 H ‐furo[2,3‐ f ]chromen‐7‐one ( 1 ), together with isoquercitrin ( 2 ), was isolated from the aerial parts of Tibouchina paratropica . Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activit y towards a panel of bacterial and fungal pathogens, and compound 1 displayed potent anti‐parasitic activity against Leishmania donovani (IC 50 = 0.809 µg/mL). In addition, an 85% reduction in the secretion of the pro‐inflammatory cytokine IL‐6 was recorded when macrophages challenged with lipopolysaccharide were exposed to compound 1 , but no effect on the anti‐inflammatory IL‐10 was observed. Compound 2 showed neither anti‐parasitic nor anti‐inflammatory properties. In addition, no cytotoxic activities were observed against the human‐derived macrophage THP‐1 cells. Copyright © 2014 John Wiley & Sons, Ltd.
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