Premium
A Combination of Glucosyl Hesperidin and Caffeine Exhibits an Anti‐obesity Effect by Inhibition of Hepatic Lipogenesis in Mice
Author(s) -
Ohara Tatsuya,
Muroyama Koutarou,
Yamamoto Yoshihiro,
Murosaki Shinji
Publication year - 2015
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5258
Subject(s) - hesperidin , lipogenesis , caffeine , endocrinology , medicine , chemistry , adipose tissue , diet induced obese , obesity , pharmacology , insulin resistance , alternative medicine , pathology
To develop an anti‐obesity agent, we examined the combination effect of glucosyl hesperidin (G‐hesperidin) and caffeine on obesity in mice. High‐fat diet‐induced obese KK mice were fed a low‐fat diet with or without G‐hesperidin, caffeine, or their combination for 2 weeks. Decreases in body weight and significantly lower adipose tissue weight were observed in the combination‐fed mice but not in the G‐hesperidin‐fed or caffeine‐fed mice. DNA microarray analysis of mouse liver suggested that the feeding of G‐hesperidin + caffeine was associated with lower lipogenesis. Therefore, we examined the anti‐lipogenic effect of G‐hesperidin + caffeine in fasted–refed KK mice. Hepatic triglyceride levels were significantly lower in the mice fed G‐hesperidin + caffeine during the refeeding period but not in the mice fed each alone. In addition, hepatic expressions of genes related to lipogenesis, such as sterol regulatory element‐binding protein‐1c or fatty acid synthase, were significantly lower in the mice fed G‐hesperidin + caffeine compared with that in the control mice. These results suggested that G‐hesperidin + caffeine is effective for controlling obesity partly by the inhibition of hepatic lipogenesis. Copyright © 2014 John Wiley & Sons, Ltd.