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A Chemically Standardized Extract of Ziziphus jujuba Fruit (Jujube) Stimulates Expressions of Neurotrophic Factors and Anti‐oxidant Enzymes in Cultured Astrocytes
Author(s) -
Chen Jianping,
Yan Artemis L.,
Lam Kelly Y. C.,
Lam Candy T. W.,
Li Ning,
Yao Ping,
Xiong Aizhen,
Dong Tina T. X.,
Tsim Karl W. K.
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5202
Subject(s) - ziziphus jujuba , neurotrophic factors , neurotrophin , neuroprotection , biochemistry , enzyme , glutamate receptor , nerve growth factor , brain derived neurotrophic factor , glial cell line derived neurotrophic factor , biology , chemistry , pharmacology , botany , receptor
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement worldwide. To study the role of jujube in brain benefits, the expression of neurotrophic factors and anti‐oxidant enzymes in the jujube‐treated cultured astrocytes was determined. Application of a chemical standardized water extract of jujube in cultured astrocytes for 24 h stimulated the expressions of nerve growth factor, brain‐derived neurotrophic factor and glial cell line‐derived neurotrophic factor in a concentration‐dependent manner. The pre‐treatment with H89, a protein kinase A inhibitor, attenuated the jujube‐induced expression of neurotrophic factors. In parallel, the treatment of jujube water extract induced the transcriptional expressions of the enzymes responsible for anti‐oxidation, i.e. NAD(P)H: quinine oxidoreductase 1, glutamate‐cysteine ligase catalytic subunit, glutamate‐cysteine ligase modifier subunit and glutathione S‐transferase, in a concentration‐dependent manner. These results proposed the benefits of jujube in regulating expressions of neurotrophic factors and anti‐oxidant enzymes in cultured astrocytes. Copyright © 2014 John Wiley & Sons, Ltd.