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Xanthine Oxidase Inhibitory Activity of Hungarian Wild‐Growing Mushrooms
Author(s) -
Ványolós Attila,
OrbánGyapai Orsolya,
Hohmann Judit
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5115
Subject(s) - xanthine oxidase , mushroom , ic50 , inhibitory postsynaptic potential , chloroform , chemistry , agaricales , edible mushroom , traditional medicine , methanol , food science , biochemistry , botany , biology , enzyme , chromatography , in vitro , organic chemistry , medicine , taxonomy (biology) , neuroscience
Mushrooms represent a remarkable and yet largely unexplored source of new, biologically active natural products. In this work, we report on the xanthine oxidase (XO) inhibitory activity of 47 wild‐growing mushrooms native to Hungary. Aqueous and organic ( n ‐hexane, chloroform, and 50% methanol) extracts of selected mushrooms from different families were screened for their XO inhibitory activities. Among the 188 extracts investigated, the chloroform and 50% methanol fractions proved to be the most effective. Some species exhibited high inhibitory activity, e.g., Hypholoma fasciculare (IC 50 = 67.76 ± 11.05 µg/mL), Suillus grevillei (IC 50 = 13.28 ± 1.58 µg/mL), and Tricholoma populinum (IC 50 = 85.08 ± 15.02 µg/mL); others demonstrated moderate or weak activity. Additional studies are warranted to characterize the compounds responsible for the XO inhibitory activity of mushroom extracts. Copyright © 2014 John Wiley & Sons, Ltd.