Premium
Pharmacological Studies on the Antispasmodic, Bronchodilator and Anti‐Platelet Activities of Abies webbiana
Author(s) -
Yasin Mamoona,
Hussain Janbaz Khalid,
Imran Imran,
Gilani AnwarulHassan,
Bashir Samra
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5112
Subject(s) - antispasmodic , verapamil , carbachol , pharmacology , epinephrine , bronchodilator , platelet , chemistry , pharmacognosy , anesthesia , biological activity , medicine , calcium , biochemistry , asthma , receptor , in vitro
This study evaluated the antispasmodic, bronchodilator and anti‐platelet activities of Abies webbiana to rationalize some of its folk uses in gut and airways disorders and inflammation. The crude extract of A. webbiana (Aw.Cr) caused a complete relaxation of both spontaneous and K + (80 mM)‐induced contractions in isolated rabbit jejunum in a concentration‐dependent manner. Aw.Cr shifted the Ca ++ concentration–response curves (CRCs) to the right, in a fashion similar to verapamil, confirming its Ca ++ channel blocking (CCB) effect. In isolated rabbit tracheal preparations, it caused relaxation of carbachol (1 μM) and K + (80 mM)‐induced contractions comparable to verapamil suggesting that the bronchodilatory effect may possibly be mediated through CCB activity. Aw.Cr was found to be the inhibitor of both ADP‐ and epinephrine‐induced aggregation of human platelets thereby suggesting therapeutic potential in this plant against thrombo‐embolic conditions. The exhibited anti‐platelet effect was observed at low doses against epinephrine as compared to ADP. This study confirmed the presence of spasmolytic activity in Abies webbiana through possible blockade of Ca ++ channels providing evidence for its folkloric use in gut and respiratory disorders in addition to anti‐platelet activity. Copyright © 2014 John Wiley & Sons, Ltd.