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Flavonoid glycosides from the stem bark of Margaritaria discoidea demonstrate antibacterial and free radical scavenging activities
Author(s) -
Ekuadzi Edmund,
Dickson Rita,
Fleischer Theophilus,
Annan Kofi,
Pistorius Dominik,
Oberer Lukas,
Gibbons Simon
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5053
Subject(s) - flavonoid , glycoside , antibacterial activity , traditional medicine , staphylococcus aureus , chemistry , bark (sound) , reactive oxygen species , polyphenol , antioxidant , biology , bacteria , biochemistry , medicine , stereochemistry , ecology , genetics
One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea , which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin‐8‐ C ‐[ α ‐rhamnopyranosyl‐(1 → 6)]‐ β ‐glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free‐radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds. Copyright © 2013 John Wiley & Sons, Ltd.