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American Skullcap ( Scutellaria lateriflora ): A Randomised, Double‐Blind Placebo‐Controlled Crossover Study of its Effects on Mood in Healthy Volunteers
Author(s) -
Brock Christine,
Whitehouse Julie,
Tewfik Ihab,
Towell Tony
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5044
Subject(s) - placebo , mood , crossover study , profile of mood states , anxiety , medicine , anxiolytic , statistical significance , double blind , cephalalgia , beck anxiety inventory , beck depression inventory , psychology , psychiatry , alternative medicine , pathology , migraine
Scutellaria lateriflora , a traditional herbal remedy for stress and anxiety, was tested on human volunteers for its effects on mood. In a placebo‐controlled, double‐blind, crossover study, 43 healthy participants were randomised to a sequence of three times daily S. lateriflora (350 mg) or placebo, each over two weeks. In this relatively non‐anxious population (81% were mildly anxious or less, i.e. Beck Anxiety Inventory (BAI) scores ≤ 15), there was no significant difference between skullcap and placebo with BAI ( p = 0.191). However, there was a significant group effect ( p = 0.049), suggesting a carryover effect of skullcap. For Total Mood Disturbance measured by the Profile of Mood States, there was a highly significant ( p = <0.001) decrease from pre‐test scores with skullcap but not placebo ( p = 0.072). The limitations of carryover effect, generally low anxiety scores and differences in anxiety levels between groups at baseline ( p = 0.022), may have reduced the chances of statistical significance in this study. However, as S. lateriflora significantly enhanced global mood without a reduction in energy or cognition, further study assessing its putative anxiolytic effects in notably anxious subjects with co‐morbid depression is warranted. Copyright © 2013 John Wiley & Sons, Ltd.