Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis | Zendy

Mo Jiao | Zendy; Panichayupakaranant Pharkphoom | Zendy; Kaewnopparat Nattha | Zendy; Songkro Sarunyoo | Zendy; Reanmongkol Wantana | Zendy

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Topical Anti‐inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis

Author(s) -

Mo Jiao,

Panichayupakaranant Pharkphoom,

Kaewnopparat Nattha,

Songkro Sarunyoo,

Reanmongkol Wantana

Publication year - 2014

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.5039

Subject(s) - ellagic acid , edema , triamcinolone acetonide , pharmacology , diclofenac , myeloperoxidase , contact dermatitis , medicine , chemistry , inflammation , biochemistry , immunology , allergy , polyphenol , antioxidant

The present study evaluated the topical anti‐inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol‐induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose‐dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright © 2013 John Wiley & Sons, Ltd.

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