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Treatment of Primary Chronic Glomerulonephritis with Rehmannia Glutinosa Acteosides in Combination with the Angiotensin Receptor Blocker Irbesartan: A Randomized Controlled Trial
Author(s) -
Qiu HongYu,
Fu Ping,
Fan WenXing,
Zuo Chuan,
Feng Ping,
Shi Peng,
Cao Lina,
Liu Fang,
Zhou Li,
Chen Feng,
Zhong Hui,
Gou ZhongPing,
Liang YaPing,
Shi Mei
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4973
Subject(s) - irbesartan , medicine , rehmannia glutinosa , tripterygium wilfordii , proteinuria , renal function , angiotensin ii , urology , aspartate transaminase , pharmacology , gastroenterology , blood pressure , kidney , pathology , chemistry , biochemistry , alkaline phosphatase , alternative medicine , enzyme , traditional chinese medicine
This study aims to assess the efficacy and safety of Rehmannia glutinosa acteosides used in combination with the angiotensin receptor blocker irbesartan to treat primary chronic glomerulonephritis. A total of 479 patients diagnosed with primary chronic glomerulonephritis were recruited from outpatient clinics and were randomly assigned to the treatment group (Rehmannia glutinosa acteosides, two 200‐mg capsules, bid; and irbesartan, one 150‐mg tablet, qd) or the control group (irbesartan, one 150‐mg tablet, qd). The primary outcome was 24‐h urinary protein. Secondary outcome measures included blood pressure, estimated glomerular filtration rate, erythrocyturia, serum alanine aminotransferase, aspartate transaminase and electrolytes. After 8 weeks of treatment, the treatment group showed a mean reduction in 24‐h proteinuria of 36.42% compared to baseline, which was significantly higher than the mean reduction from baseline of 27.97% in the control group ( P = 0.0278).Adverse drug reactions occurred at a similarly low rate in the treatment group (0.4%) and control group (1.2%, P = 0.3724). In the treatment of chronic glomerulonephritis, the combination of Rehmannia glutinosa acteosides and irbesartan can reduce proteinuria more effectively than irbesartan alone. Copyright © 2013 John Wiley & Sons, Ltd.