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Antiplatelet Activity of a Novel Formula Composed of Malic Acid, Succinic Acid and Citric Acid from Cornus officinalis Fruit
Author(s) -
Zhang QiChun,
Zhao Yue,
Bian HuiMin
Publication year - 2013
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4934
Subject(s) - malic acid , succinic acid , citric acid , officinalis , chemistry , pharmacognosy , botany , traditional medicine , food science , biology , medicine , biochemistry , biological activity , in vitro
The present study investigated the antiplatelet activity of a novel formula composed by malic acid, succinic acid and citric acid with a ratio of 3:2:2. The IC 50 and inhibition of platelet aggregation induced by various agonists as well as platelet adhesion were evaluated in vitro . Of note, the IC 50 for the formula inhibiting adenosine diphosphate (ADP)‐induced platelet aggregation was 0.185 mg/mL. Meanwhile, the formula showed more potent inhibitory effect on platelet aggregation induced by ADP and thrombin than the single component at same concentration (0.37 mg/mL). Moreover, the formula could prevent platelet adhesion significantly without influence on platelet viability. Copyright © 2013 John Wiley & Sons, Ltd.