Antiplatelet Activity of a Novel Formula Composed of Malic Acid, Succinic Acid and Citric Acid from  Cornus officinalis  Fruit | Zendy

Zhang QiChun | Zendy; Zhao Yue | Zendy; Bian HuiMin | Zendy

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Antiplatelet Activity of a Novel Formula Composed of Malic Acid, Succinic Acid and Citric Acid from Cornus officinalis Fruit

Author(s) -

Zhang QiChun,

Zhao Yue,

Bian HuiMin

Publication year - 2013

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.4934

Subject(s) - malic acid , succinic acid , citric acid , officinalis , chemistry , pharmacognosy , botany , traditional medicine , food science , biology , medicine , biochemistry , biological activity , in vitro

The present study investigated the antiplatelet activity of a novel formula composed by malic acid, succinic acid and citric acid with a ratio of 3:2:2. The IC 50 and inhibition of platelet aggregation induced by various agonists as well as platelet adhesion were evaluated in vitro . Of note, the IC 50 for the formula inhibiting adenosine diphosphate (ADP)‐induced platelet aggregation was 0.185 mg/mL. Meanwhile, the formula showed more potent inhibitory effect on platelet aggregation induced by ADP and thrombin than the single component at same concentration (0.37 mg/mL). Moreover, the formula could prevent platelet adhesion significantly without influence on platelet viability. Copyright © 2013 John Wiley & Sons, Ltd.

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