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Antimicrobial, antioxidant and anti‐inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop
Author(s) -
Marčetić Mirjana,
Božić Dragana,
Milenković Marina,
Malešević Nevenka,
Radulović Siniša,
Kovačević Nada
Publication year - 2013
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4919
Subject(s) - ethyl acetate , antimicrobial , dpph , chemistry , antioxidant , candida albicans , traditional medicine , chloroform , ic50 , lipid peroxidation , pharmacognosy , food science , botany , biochemistry , biological activity , chromatography , biology , in vitro , organic chemistry , medicine
In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram‐positive and Gram‐negative bacteria (MIC 25–200 µg/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 µg/ml). The ethyl acetate fraction exhibited a significant ferric‐reducing ability (10.7 mmol Fe 2+ /g extract), a very high DPPH radical scavenging activity (SC 50 = 1.7 µg/ml) and inhibition of lipid peroxidation (IC 50 = 41.8 µg/ml). High amounts of total phenolics (929.8 mg/g), tannins (833.8 mg/g) and flavonoids (35.5 mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti‐inflammatory (76.7%) and cytotoxic effects (IC 50 = 15.6 µg/ml). Copyright © 2012 John Wiley & Sons, Ltd.