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Genotoxic and Antigenotoxic Activity of Acerola ( Malpighia glabra L.) Extract in Relation to the Geographic Origin
Author(s) -
Da Silva Nunes Roberta,
Silva Kahl Vivian Francília,
Da Silva Sarmento Merielen,
Richter Marc François,
AbinCarriquiry Juan Andres,
Martinez Marcela María,
De Barros Falcão Ferraz Alexandre,
Da Silva Juliana
Publication year - 2013
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4896
Subject(s) - traditional medicine , biology , pharmacognosy , ascorbic acid , botany , biological activity , medicine , food science , in vitro , biochemistry
Malpighia glabra L, popularly known as acerola, is considered a functional fruit and therefore is taken to prevent disease or as adjuvant to treatment strategies, since the fruit is an undeniable source of vitamin C, carotenoids, and flavonoids. Acerola is a natural source of vitamin C, flavonoids, and carotenoids. Its chemical composition is affected by genetic uniformity of the orchards and environmental factors. Considering the extensive growth of the culture of acerola in Brazil as well as its widespread use, this study evaluates the genotoxic and antigenotoxic activity of acerola in relation to geographical origin using the comet assay in mice blood cells in vitro . No acerola samples showed potential to induce DNA damage, independently of origin. Also, for antigenotoxicity activity, only the acerola sample from São Paulo reduced DNA damage induced by hydrogen peroxide (by about 56%). The sample from Ceará showed good antioxidant activity by the 2,2‐diphenyl‐1‐picrylhydrazyl assay, in agreement with its higher rutin, quercetin, and vitamin C levels. Additional studies with other treatment regimens are necessary to better understand the impact of the complex mixture of acerola on genomic stability. Copyright © 2012 John Wiley & Sons, Ltd.