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In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin‐Resistant Staphylococcus aureus
Author(s) -
Eom SungHwan,
Kim DoHyung,
Lee SangHoon,
Yoon NaYoung,
Kim Ji Hoe,
Kim Tae Hoon,
Chung YongHyun,
Kim SeonBong,
Kim YoungMan,
Kim HyunWoo,
Lee MyungSuk,
Kim YoungMog
Publication year - 2013
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4851
Subject(s) - staphylococcus aureus , antibiotics , antibacterial activity , penicillin , microbiology and biotechnology , ampicillin , methicillin resistant staphylococcus aureus , minimum inhibitory concentration , antibacterial agent , chemistry , bacteria , biology , genetics
Six phlorotannins, isolated from Eisenia bicyclis , were evaluated for antibacterial activity against methicillin‐resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol‐A (PFF) exhibited the highest anti‐MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β‐lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti‐MRSA activity of phlorotannins from E. bicyclis . The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA. Copyright © 2012 John Wiley & Sons, Ltd.