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Suppressive Effect of Flavonoids from Korean Citrus aurantium L. on the Expression of Inflammatory Mediators in L6 Skeletal Muscle Cells
Author(s) -
Kim JinA.,
Park HyeonSoo,
Kang SangRim,
Park KwangIl,
Lee DoHoon,
Nagappan ArulKumar,
Shin SungChul,
Lee WonSup,
Kim EunHee,
Kim GonSup
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4666
Subject(s) - skeletal muscle , nitric oxide , inflammation , tumor necrosis factor alpha , lipopolysaccharide , nitric oxide synthase , signal transduction , chemistry , kinase , anti inflammatory , nf κb , pharmacology , biochemistry , traditional medicine , biology , medicine , immunology , endocrinology , organic chemistry
Citrus fruits ( Citrus aurantium L.) have long been used as a traditional herbal medicine. The benefits of the flavonoids found in Citrus aurantium L. include anti‐inflammation, anti‐cancer, anti‐viral and anti‐bacterial activities, and enhancement of the immune response. The study investigated the effect of the flavonoids isolated from Citrus aurantium L. native to Korea on the production of pro‐inflammatory mediators by blocking signal transduction mediated by nuclear factor‐kappa B (NF‐κB) and mitogen‐activated protein kinases (MAPKs) in lipopolysaccharide (LPS)‐induced L6 skeletal muscle cells. The flavonoids decreased the production of inducible nitric oxide synthase, cyclooxygenase‐2, interleukin‐6 and tumor necrosis factor‐alpha by suppressing NF‐κB and MAPKs signal pathways in LPS‐induced L6 skeletal muscle cells. These findings suggest that the flavonoids isolated from Korea Citrus aurantium L. might have anti‐inflammatory effects that regulate the expression of inflammatory mediators in L6 skeletal muscle cells. Copyright © 2012 John Wiley & Sons, Ltd.