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Kavalactone Metabolism in the Isolated Perfused Rat Liver
Author(s) -
Fu Shuang,
Rowe Anthony,
Ramzan Iqbal
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4656
Subject(s) - metabolism , chemistry , excretion , metabolic pathway , pharmacology , biochemistry , medicine , endocrinology , biology
Metabolic pathways for kavalactone metabolism in humans and rats have been identified, but more detailed description of the enzyme kinetics involved is lacking. The disposition profiles of three of the six major kavalactones (kavain, methysticin and desmethoxyyangonin) and their respective metabolites ( p ‐hydroxykavain, m,p ‐dihydroxykavain and p ‐hydroxy‐5,6‐dehydrokavain) were examined in the perfusate and bile of the isolated perfused rat liver. The metabolism of the kavalactones is first‐order in nature with similar decay half‐lives. p ‐Hydroxykavain and m,p ‐dihydroxykavain were the only metabolites detected in the perfusate. Kavalactone biliary excretion was negligible. Copyright © 2012 John Wiley & Sons, Ltd.