Antioxidant and Anti‐α‐glucosidase Compounds from the Rhizome of  Peltiphyllum peltatum  (Torr.) Engl | Zendy

Habtemariam Solomon | Zendy; Cowley Raymond A. | Zendy

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Antioxidant and Anti‐α‐glucosidase Compounds from the Rhizome of Peltiphyllum peltatum (Torr.) Engl

Author(s) -

Habtemariam Solomon,

Cowley Raymond A.

Publication year - 2012

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.4626

Subject(s) - ethyl acetate , chemistry , petroleum ether , rhizome , antioxidant , gallic acid , bergenin , methyl gallate , catechin , ethanol , alcohol , organic chemistry , chloroform , chromatography , traditional medicine , food science , polyphenol , extraction (chemistry) , medicine

The antioxidant, anti‐α‐glucosidase and anticholinesterase effects of the alcohol extract of fresh underground rhizomes of Peltiphyllum peltatum were studied. A potent antioxidant activity accompanied by a selective α‐glucosidase effect was observed for the crude extract. Further activity‐guided fractionation (petroleum ether, chloroform, ethyl acetate, n ‐butanol and water) resulted in the identification of the ethyl acetate fraction with the highest antioxidant effect. Gallic acid, methyl‐3‐ O ‐methyl gallate, catechin, gallocatechin, bergenin and 11‐ O ‐galloylbergenin were isolated from the ethyl acetate fraction. While all the isolated compounds did show a variable degree of radical scavenging effect, 11‐ O ‐galloylbergenin was identified as the selective α‐glucosidase inhibitor. The isolation, structural elucidation and biological effects of these compounds are discussed. Copyright © 2012 John Wiley & Sons, Ltd.

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