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Bioactive Compounds from Carissa spinarum
Author(s) -
Wangteeraprasert Ruchira,
Lipipun Vimolmas,
Gunaratnam Mekala,
Neidle Stephen,
Gibbons Simon,
Likhitwitayawuid Kittisak
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.4607
Subject(s) - dpph , glycoside , herpes simplex virus , coumarin , traditional medicine , cytotoxicity , biological activity , antioxidant , antibacterial activity , chemistry , biology , stereochemistry , biochemistry , bacteria , virus , medicine , in vitro , organic chemistry , virology , genetics
In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from the stems of Carissa spinarum L. was found to possess appreciable activity against herpes simplex viruses (HSV I and II). A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. The cardiac glycoside evomonoside was found to be the only antiherpetic principle, showing moderate activity against herpes simplex virus types I and II in the inactivation method. The lignans (−)‐carinol, (−)‐carissanol and (−)‐nortrachelogenin exhibited cytotoxicity against breast (MCF7) and lung (A549) cancer cells. Moderate anti‐DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity. Copyright © 2012 John Wiley & Sons, Ltd.