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Antiobesity Effects of a Sulfur Compound Thiacremonone Mediated via Down‐regulation of Serum Triglyceride and Glucose Levels and Lipid Accumulation in the Liver of db/db Mice
Author(s) -
Ban Jung Ok,
Lee Dong Hun,
Kim Eun Jin,
Kang Jeong Woo,
Kim Man Sub,
Cho Min Chul,
Jeong Heon Sang,
Kim Jong Wan,
Yang Young,
Hong Jin Tae,
Yoon Do Young
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3729
Subject(s) - triglyceride , endocrinology , medicine , lipid metabolism , fatty acid synthase , acetyl coa carboxylase , fatty liver , peroxisome proliferator activated receptor , beta oxidation , fatty acid , peroxisome , chemistry , carbohydrate metabolism , metabolism , pharmacology , biology , receptor , biochemistry , pyruvate carboxylase , cholesterol , enzyme , disease
Garlic is widely used as a spice. Garlic extracts exert anticancer and antiinflammatory effects, but its antiobesity efficacy studies have produced conflicting results. The antiobesity effects of thiacremonone, a sulfur compound isolated from garlic, was evaluated in obese db / db mice. Thiacremonone was orally administrated to mice for 3 weeks. The thiacremonone‐treated db / db mice showed a loss of body weight and decrease in blood triglyceride and glucose levels compared with the control mice. Histological analysis further revealed that thiacremonone significantly decreased lipid accumulation in the fatty livers of treated db/db mice. It was observed that GLUT‐4 expression and glucose uptake were up‐regulated by thiacremonone in 3T3‐L1 adipocytes. Thiacremonone treatment also suppressed expression levels of acetyl‐CoA carboxylase (ACC) and fatty acid synthase (FAS), which are involved in lipid metabolism, in the liver of db/db mice. In addition, thiacremonone enhanced peroxisome proliferator‐activated receptor γ (PPARγ) expression in the fatty liver. Taken together, these results suggest that thiacremonone may play a vital role in improving the management of obesity and related metabolic syndromes via inhibition of lipid accumulation. Copyright © 2012 John Wiley & Sons, Ltd.