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Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L.
Author(s) -
Nguyen Mai Thanh Thi,
Nguyen Nhan Trung
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3710
Subject(s) - xanthine oxidase , allopurinol , inhibitory postsynaptic potential , chemistry , pharmacognosy , traditional medicine , positive control , stereochemistry , enzyme , biological activity , biochemistry , biology , in vitro , medicine , pathology , neuroscience
From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2 R ,3 S )‐(−)‐4′‐ O ‐methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–4 and 6–8 displayed significant xanthine oxidase inhibitory activity in a concentration‐dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC 50 values ranging from 0.23 to 1.91 µ m , than that of a positive control allopurinol (IC 50 2.50 µ m ). Copyright © 2012 John Wiley & Sons, Ltd.