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Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats
Author(s) -
Huang Mingqing,
Xie Youliang,
Chen Lidian,
Chu Kedan,
Wu Shuisheng,
Lu Jinjian,
Chen Xiuping,
Wang Yitao,
Lai Xiaoping
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3654
Subject(s) - salvia miltiorrhiza , triglyceride , diabetes mellitus , medicine , polyphenol , streptozocin , phytotherapy , streptozotocin , cholesterol , insulin , blood urea nitrogen , traditional medicine , pharmacology , endocrinology , antioxidant , chemistry , traditional chinese medicine , biochemistry , kidney , alternative medicine , pathology
An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo . Copyright © 2011 John Wiley & Sons, Ltd.