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The Sustained Influence of Short Term Exposure to a Proprietary Extract of North American Ginseng on the Hemopoietic Cells of the Bone Marrow, Spleen and Blood of Adult and Juvenile Mice
Author(s) -
Miller Sandra C.,
Ti Lianping,
Shan Jacqueline J.
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3626
Subject(s) - haematopoiesis , spleen , ginseng , bone marrow , immune system , biology , immunology , juvenile , blood cell , andrology , splenocyte , stem cell , medicine , pathology , microbiology and biotechnology , genetics , alternative medicine
This study assessed the influences of CVT‐E002, a proprietary extract of North American ginseng, Panax quinquefolius (Afexa Life Sciences, Inc., Edmonton, AB, Canada), in vivo , on murine hemopoietic and immune cells when administered as a dietary additive. The extract was given daily to young, adult mice for a period of 4 weeks, immediately following which one group was euthanized and the hemopoietic and immune cells of their bone marrow, spleen and blood were assayed for CVT‐E002‐mediated alterations in any of five cell lineages (lymphocytes, nucleated erythroid cells, granulocytes, immature granuloid precursors and monocytes). Another group of these mice was left for a subsequent 8 weeks on control diet, following which the same organs and cell lineages were analysed. In another study, juvenile mice immediately upon weaning (age: 4 weeks), were subjected to the above protocol, and their organs/cell lineages assayed. The results revealed that CVT‐E002 had a long‐lasting, positive quantitative effect on the lymphocytes and monocytes, regardless of age at commencement of daily, dietary CVT‐E002. CVT‐E002 may therefore have a prophylactic disease defense, immunostimulatory role, or potentially, even a therapeutic role. Copyright © 2011 John Wiley & Sons, Ltd.