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Effect of Bacoside Extract from Bacopa monniera on Physical Fatigue Induced by Forced Swimming
Author(s) -
Anand T.,
Phani Kumar G.,
Pandareesh M. D.,
Swamy M. S. L.,
Khanum Farhath,
Bawa A. S.
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3611
Subject(s) - superoxide dismutase , malondialdehyde , catalase , blood urea nitrogen , creatine kinase , lipid peroxidation , pharmacology , glycogen , antioxidant , creatine , medicine , western blot , chemistry , endocrinology , traditional medicine , biochemistry , creatinine , gene
The antifatigue effect of bacoside extract (BME) from Bacopa monniera (L.) Wettst. was investigated. Rats were subjected to weight‐loaded forced swim test (WFST) every alternate day for 3 weeks. The BME at a dosage of 10 mg/kg body weight was administered orally to rats for 2 weeks in order to evaluate the following biomarkers of physical fatigue: swimming time, change in body weight, lipid peroxidation, lactic acid (LA), glycogen, antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT) and blood parameters, namely blood urea nitrogen (BUN) and creatine kinase (CK). The exhaustive swimming time was increased by 3‐fold in the BME supplemented group compared with that of the control group on day 13. The BME treatment lowered malondialdehyde (MDA) levels in brain, liver and muscle tissues by 11.2%, 16.2% and 37.7%, respectively, compared with the control exercised group ( p < 0.05). The BME also reduced the LA, serum BUN and CK activities significantly compared with that of the control. Administration of BME significantly protected the depletion of SOD and CAT activities. The HSP‐70 expression studies by western blot also confirmed the antifatigue property of BME. The present study thus indicates that BME ameliorates the various impairments associated with physical fatigue. Copyright © 2011 John Wiley & Sons, Ltd.