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Biological Activities of Indian Celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh
Author(s) -
Abbaskhan Ahmed,
Choudhary Muhammed Iqbal,
Ghayur Mohammed Nabeel,
Parween Zeba,
Shaheen Farzana,
Gilani AnwarulHassan,
Maruyama Takuro,
Iqbal Kiran,
Tsuda Yoshisuke
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3600
Subject(s) - antispasmodic , traditional medicine , antioxidant , yeast , pharmacognosy , folk medicine , ether , cytotoxicity , biological activity , chemistry , medicine , biochemistry , in vitro , organic chemistry
In continuation of our work on Indian celery ( Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH–H 2 O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant. Copyright © 2011 John Wiley & Sons, Ltd.