Evaluation of the Antipsoriatic Activity of  Aloe Vera  Leaf Extract Using a Mouse Tail Model of Psoriasis | Zendy

Dhanabal S. P. | Zendy; Priyanka Dwarampudi L. | Zendy; Muruganantham N. | Zendy; Vadivelan R. | Zendy

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Evaluation of the Antipsoriatic Activity of Aloe Vera Leaf Extract Using a Mouse Tail Model of Psoriasis

Author(s) -

Dhanabal S. P.,

Priyanka Dwarampudi L.,

Muruganantham N.,

Vadivelan R.

Publication year - 2012

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3589

Subject(s) - aloe vera , tazarotene , psoriasis , dermatology , traditional medicine , medicine , pharmacognosy , positive control , chemistry , pharmacology , biological activity , in vitro , biochemistry

Aloe vera gel is used traditionally for the treatment of skin diseases, including psoriasis. An ethanolic extract of the gel was assessed for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%). This was equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis. The ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, whereas the standard tazarotene showed no change. Taken together, the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis. Copyright © 2011 John Wiley & Sons, Ltd.

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