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Baicalin Down‐regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis
Author(s) -
Dai ShiXue,
Zou Ying,
Feng YanLing,
Liu HongBo,
Zheng XueBao
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3581
Subject(s) - macrophage migration inhibitory factor , baicalin , chemokine , mesalazine , ulcerative colitis , macrophage , pharmacology , inflammation , proinflammatory cytokine , immunology , chemistry , medicine , in vitro , cytokine , biochemistry , high performance liquid chromatography , disease , chromatography
The purpose of this study was to investigate whether baicalin, a Chinese herbal extract, down‐regulates the expression of macrophage migration inhibitory factor (MIF), an inflammatory factor that regulates the function of macrophages (MΦ), in rats with trinitrobenzene sulphonic acid (TNBS)‐induced ulcerative colitis (UC). The results showed that baicalin simultaneously down‐regulated the expression of MIF, the quantity of MΦs and the amount of MΦ‐related cytokines, including macrophage chemotactic factor‐1 (MCP‐1, CCL2) and macrophage inflammatory protein‐3α (MIP‐3α, CCL20), in rats with UC. There was no statistical difference between baicailin and mesalazine in down‐regulating the expression of MIF. Our study demonstrated that baicalin, an inexpensive but effective monomer, could be a new and alternative pharmaceutical for UC. Copyright © 2011 John Wiley & Sons, Ltd.