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Topical Application of Two Condensed Tannins from the Root of Rosa multiflora Thunberg for the Treatment of Atopic Dermatitis (AD) in NC/Nga Mice
Author(s) -
Park Kwan Hee,
Choi Sun Eun,
Choi Young Wook,
Lee Do Ik,
Joo Seong Soo,
Jeong Mi Sook,
Bang Hyoweon,
Lee Chung Soo,
Lee MiKyung,
Seo Seong Jun,
Lee Min Won
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3578
Subject(s) - atopic dermatitis , proanthocyanidin , medicine , phytotherapy , catechin , traditional medicine , bark (sound) , rheumatoid arthritis , dermatology , polyphenol , chemistry , immunology , biology , biochemistry , pathology , antioxidant , ecology , alternative medicine
Recently, the isolation of several condensed tannins from the roots of Rosa multiflora Thunberg, a traditional herbal therapy in oriental medicine for rheumatoid arthritis and scabies, was described. Two of the major condensed tannins – procyanidin B‐3 (ProB3) and ent ‐guibourtinidol‐(4 β → 6)‐catechin (RM‐1) – were then applied topically to atopic dermatitis‐like skin lesions on NC/Nga mice in order to assess their immunomodulatory properties. Both ProB3 and RM‐1 significantly reduced the serum levels of eosinophils, IgE and certain Th2 cytokines (IL‐4, 5 and 13) ( p < 0.05 or 0.01). Additionally, ProB3 and RM‐1 significantly reduced both the mRNA and protein expression of COX‐2 and iNOS in mouse skin tissues ( p < 0.01). Such results strongly suggest that ProB3 and RM‐1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis. Copyright © 2011 John Wiley & Sons, Ltd.