Premium
Acetyl‐ and Butyryl‐cholinesterase Inhibitory Activities of Mansorins and Mansonones
Author(s) -
Changwong Nisa,
Sabphon Chalisa,
Ingkaninan Kornkanok,
Sawasdee Pattara
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3576
Subject(s) - acetylcholinesterase , cholinesterase , butyrylcholinesterase , aché , inhibitory postsynaptic potential , chemistry , in vivo , pharmacology , enzyme , biology , biochemistry , neuroscience , microbiology and biotechnology
Cholinesterase (ChE) inhibitory activities of three coumarins (mansorins A–C) and five naphthoquinones (mansonone C, E, G and H) were evaluated to determine the relationships between the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory effects and the core structures of these compounds. Among the tested compounds, mansonone E exhibited the highest ChE inhibitory activities, with IC 50 values in the low micromolar levels. In addition to revealing the ChE inhibitory activities of naphthoquinones for the first time, the results also revealed structure–activity relationship information that could be useful for further modification. Furthermore, the study also supports the hypothesis that mansonones are the active component in Thespesia populnea , a plant that previously has been shown to enhance memory activity in an in vivo study. Copyright © 2011 John Wiley & Sons, Ltd.