Premium
Mechanisms of Olive Leaf Extract‐Ameliorated Rat Arthritis Caused by Kaolin and Carrageenan
Author(s) -
Gong Dezheng,
Geng Chengyan,
Jiang Liping,
Wang Lihui,
Yoshimura Hiroyuki,
Zhong Laifu
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3567
Subject(s) - carrageenan , medicine , arthritis , myeloperoxidase , pharmacology , traditional medicine , antioxidant , croton oil , phytotherapy , edema , swelling , inflammation , chemistry , immunology , biochemistry , pathology , alternative medicine
Olive leaf extract (OLE) has antioxidant and antiinflammatory actions. However, the role of OLE in mechanical inflammatory arthritis (osteoarthritis, OA) is unclear. This study investigated the effect of OLE on the development of kaolin and carrageenan‐induced arthritis, a murine model of OA. Administration of OLE significantly ameliorated paw swelling, the paw Evans blue content and the histopathological scores. In the human monocyte cell line, THP‐1, the OLE reduced the LPS‐induced TNF‐α production and was dose dependent. Croton oil‐induced ear edema in mice also revealed that treatment with OLE suppressed ear edema, myeloperoxidase (MPO) production and was dose dependent. These results indicated that OLE is an effective antiarthritis agent through an antiinflammation mechanism. Also OLE may be beneficial for the treatment of OA in humans. Copyright © 2011 John Wiley & Sons, Ltd.