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Analgesic and Antiinflammatory Activity of Kaur‐16‐en‐19‐oic acid from Annona reticulata L. Bark
Author(s) -
Chavan Machindra J.,
Kolhe Dinesh R.,
Wakte Pravin S.,
Shinde Devanand B.
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3544
Subject(s) - analgesic , (+) naloxone , annona , carrageenan , traditional medicine , chemistry , bark (sound) , pharmacognosy , pharmacology , annona muricata , acetic acid , biological activity , hot plate , medicine , in vitro , opioid , biology , biochemistry , annonaceae , ecology , receptor , mechanical engineering , engineering
Kaur‐16‐en‐19‐oic acid was isolated from the bark of Annona reticulata and studied for its analgesic and antiinflammatory activity. Analgesic activity was assessed using the hot plate test and acetic acid‐induced writhing, and the antiinflammatory activity using the carrageenan induced rat paw oedema method. Kaur‐16‐en‐19‐oic acid, at doses of 10 and 20 mg/kg, exhibited significant ( p < 0.05) analgesic and antiinflammatory activity. These activities were comparable to the standard drugs used, and furthermore the analgesic effect of kaur‐16‐en‐19‐oic acid was blocked by naloxone (2 mg/kg) in both analgesic models. Copyright © 2011 John Wiley & Sons, Ltd.