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Protective Effect of Pycnogenol® on Ovariectomy‐induced Bone Loss in Rats
Author(s) -
Mei Lin,
Mochizuki Miyako,
Hasegawa Noboru
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3541
Subject(s) - ovariectomized rat , bone mineral , medicine , endocrinology , quantitative computed tomography , bone density , osteocalcin , bone remodeling , n terminal telopeptide , chemistry , osteoporosis , femur , estrogen , surgery , alkaline phosphatase , biochemistry , enzyme
Pycnogenol® (PYC) is a natural plant extract from the bark of Pinus pinaster and has potent antioxidant activities. The protective effect of PYC on bone loss was studied in multiparous ovariectomized (OVX) female rats. Pycnogenol® (30 or 15 mg/kg body weight/day) was administered orally to 8‐month‐old OVX rats for 3 months. At the end of the experiment, bone strength was measured by a three‐point bending test and bone mineral density was estimated by peripheral quantitative computed tomography. Ovariectomy significantly decreased femur bone strength and bone density. Supplementation with PYC suppressed the bone loss induced by OVX. The OVX treatment significantly increased serum osteocalcin (OC) and C ‐terminal telopeptide of type I collagen (CTx). Supplementation with PYC reduced the serum OC and CTx in OVX rats to a level similar to that of the sham‐operated group. The results indicated that orally administered PYC can decrease the bone turnover rate in OVX rats, resulting in positive effects on the biomechanical strength of bone and bone mineral density. Copyright © 2011 John Wiley & Sons, Ltd.