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Linseed Oil: An Investigation of its Antiarthritic Activity in Experimental Models
Author(s) -
Singh Surender,
Nair Vinod,
Gupta Y. K.
Publication year - 2012
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3535
Subject(s) - medicine , rheumatoid arthritis , granuloma , arthritis , adjuvant , pharmacology , immunology
Food sources rich in omega‐3 fatty acids have been valued for their beneficial effect in the management of inflammatory disorders. The present study evaluates the antiarthritic and immunomodulatory activity of Linum usitatissimum fixed oil (LUFO) in experimental models. The LUFO produced a dose‐dependent reduction in joint swelling and circulating TNF‐α levels in both preventive and curative protocols of arthritis induced by complete Freund's adjuvant (CFA). Expression of TNF‐R1 and Interleukin (IL) 6 proteins in the arthritic paw was also significantly reduced in the LUFO‐treated animals. In the cotton pellet induced granuloma model, LUFO treatment significantly reduced the dry granuloma weight as compared with the control group. Results of our present study thus demonstrate the antiarthritic and disease modifying activity of LUFO. We believe that dietary incorporation of LUFO may be beneficial in the prevention and management of rheumatoid arthritis and other chronic inflammatory disorders. Copyright © 2011 John Wiley & Sons, Ltd.