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The Antiangiogenic and Antinociceptive Activities of n ‐Propyl Gallate
Author(s) -
Jung HJ.,
Lim CJ.
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3452
Subject(s) - chorioallantoic membrane , endostatin , propyl gallate , umbilical vein , methyl gallate , gallate , angiogenesis , pharmacology , chemistry , biochemistry , medicine , in vitro , gallic acid , antioxidant
n ‐Propyl gallate dose‐dependently displayed an inhibitory effect on chick chorioallantoic membrane (CAM) angiogenesis. It markedly increased the endostatin level in both isolated CAM tissues and human umbilical vein endothelial cells (HUVECs). n ‐Propyl gallate was also able to enhance the endostatin mRNA level in HUVECs. Antinociceptive activity of n ‐propyl gallate was assessed using an acetic acid‐induced writhing test in mice. In brief, n ‐propyl gallate possesses antiangiogenic activity via up‐regulation of endostatin. Copyright © 2011 John Wiley & Sons, Ltd.