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Antiparasitic Activity of C ‐Geranyl Flavonoids from Mimulus bigelovii
Author(s) -
Salem Manar M.,
Capers Jeffrey,
Rito Shawn,
Werbovetz Karl A.
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3404
Subject(s) - amastigote , axenic , trypanosoma brucei , leishmania , biology , berberidaceae , antiparasitic , pharmacognosy , parasite hosting , leishmania donovani , botany , traditional medicine , biological activity , biochemistry , in vitro , bacteria , medicine , pathology , world wide web , gene , genetics , computer science
Bioactivity‐directed fractionation of the MeOH fraction of the extract of Mimulus bigelovii by means of an axenic Leishmania amastigote assay and chromatographic techniques resulted in the isolation of four C ‐geranyl flavanones, diplacone (1), 3′‐ O ‐methyldiplacone (2), 4′‐ O ‐methyldiplacone (3), 3′‐ O ‐methyldiplacol (4), together with a geranylated flavone, cannflavin A (5). These compounds were separated from M. bigelovii for the first time. All compounds showed moderate antileishmanial activity against axenic Leishmania donovani amastigotes with IC 50 values ranging from 4.8 to 14.6 μg/mL. The compounds were also tested against the related kinetoplastid parasite Trypanosoma brucei brucei and they showed activity with IC 50 values ranging from 1.4 to 7.2 μg/mL. Copyright © 2011 John Wiley & Sons, Ltd.