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Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A
Author(s) -
Monzote L.,
CuestaRubio O.,
Matheeussen A.,
Van Assche T.,
Maes L.,
Cos P.
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3401
Subject(s) - antimicrobial , candida albicans , trichophyton rubrum , chemistry , clusiaceae , microbiology and biotechnology , staphylococcus aureus , escherichia coli , antifungal , bacteria , biology , botany , biochemistry , genetics , gene
Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram‐positive bacterium Staphylococcus aureus , while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans . An interesting activity was found for Plasmodium falciparum with IC 50 values lower than 1 μ m , while cytotoxicity on MRC‐5 cells revealed CC 50 values of 15.5 and 12.0 μ m , respectively, for nemorosone and guttiferone A. Copyright © 2011 John Wiley & Sons, Ltd.