Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone  A | Zendy

Monzote L. | Zendy; CuestaRubio O. | Zendy; Matheeussen A. | Zendy; Van Assche T. | Zendy; Maes L. | Zendy; Cos P. | Zendy

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Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A

Author(s) -

Monzote L.,

CuestaRubio O.,

Matheeussen A.,

Van Assche T.,

Maes L.,

Cos P.

Publication year - 2011

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3401

Subject(s) - antimicrobial , candida albicans , trichophyton rubrum , chemistry , clusiaceae , microbiology and biotechnology , staphylococcus aureus , escherichia coli , antifungal , bacteria , biology , botany , biochemistry , genetics , gene

Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram‐positive bacterium Staphylococcus aureus , while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans . An interesting activity was found for Plasmodium falciparum with IC 50 values lower than 1 μ m , while cytotoxicity on MRC‐5 cells revealed CC 50 values of 15.5 and 12.0 μ m , respectively, for nemorosone and guttiferone A. Copyright © 2011 John Wiley & Sons, Ltd.

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