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Intracellular uptake of (‐)epicatechin by human erythrocytes as a function of human age
Author(s) -
Maurya Pawan Kumar,
Prakash Siya
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3343
Subject(s) - intracellular , function (biology) , biology , chemistry , traditional medicine , medicine , biochemistry , microbiology and biotechnology
The present studies were carried out to determine the intracellular uptake of (‐)epicatechin by erythrocytes during aging in humans. (‐)Epicatechin uptake was estimated by performing ethyl acetate extraction while the total antioxidant potential of the (‐)epicatechin was estimated in terms of FRAP (ferric reducing ability of plasma) values. A significant ( p < 0.001) decrease in (‐)epicatechin uptake by human erythrocytes was observed as a function of age. It is hypothesized that the uptake of (‐)epicatechin in human erythrocytes has an important role in the regulation of PMRS (plasma membrane redox system) activity during normal human aging. Copyright © 2010 John Wiley & Sons, Ltd.