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Bile Acid‐binding Ability of Kaki‐tannin from Young Fruits of Persimmon ( Diospyros kaki ) In Vitro and In Vivo
Author(s) -
Matsumoto Kenji,
Kadowaki Akio,
Ozaki Natsumi,
Takenaka Makiko,
Ono Hiroshi,
Yokoyama Shinichiro,
Gato Nobuki
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3306
Subject(s) - diospyros kaki , diospyros , tannin , in vivo , in vitro , traditional medicine , biology , botany , chemistry , biochemistry , medicine , microbiology and biotechnology
The bile acid‐binding ability of a highly polymerized tannin (kaki‐tannin) extracted from dried‐young fruits of persimmon ( Diospyros kaki ) was examined. The kaki‐tannin was composed mainly of epicatechin, epigallocatechin, epicatechin‐3‐ O ‐gallate and epigallocatechin‐3‐ O ‐gallate. Bile acid‐binding ability of kaki‐tannin was examined against cholic acid, glycocholic acid, taurocholic acid and deoxycholic acid in vitro , and its effect on fecal bile acid excretion in mice was also examined. Although the bile acid‐binding ability of kaki‐tannin was weaker than that of cholestyramine, kaki‐tannin adsorbed all the bile acids tested and significantly promoted fecal bile acid excretion in mice when supplied at 1% (w/w) in the diet. Copyright © 2010 John Wiley & Sons, Ltd.