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Hydrolysates of citrus plants stimulate melanogenesis protecting against UV‐induced dermal damage
Author(s) -
Chiang HsiuMei,
Lin JenWen,
Hsiao PeiLing,
Tsai ShangYuan,
Wen KuoChing
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3302
Subject(s) - melanin , naringenin , photoaging , tyrosinase , photoprotection , chemistry , hyperpigmentation , food science , skin cancer , hydrolysate , dna damage , antioxidant , flavonoid , biochemistry , dermatology , biology , hydrolysis , medicine , enzyme , dna , cancer , photosynthesis , genetics
The sun‐tanning process occurs as a spontaneous response to ultraviolet (UV) irradiation. UV will induce tanning and DNA damage, processes that can lead to photoaging and skin disorders such as hyperpigmentation and cancer. The pigment melanin protects skin from UV damage; therefore, an efficient melanin‐promoting suntan lotion could be highly beneficial. In this study, a process was developed to increase the content of naringenin in citrus extracts and to determine whether a higher naringenin content of citrus would induce melanogenesis. Melanin content and tyrosinase expression in mouse B16 melanoma cells were assayed after treatment with citrus plant extracts and their hydrolysates. The results indicate that hydrolysis increased the naringenin content in citrus extracts and that citrus preparations stimulated cellular melanogenesis and tyrosinase expression. It is suggested that this method is applicable to the industrial production of melanin‐promoting suntan lotions with antiphotocarcinogenic properties derived from citrus rind and citrus products. Copyright © 2010 John Wiley & Sons, Ltd.