Mixtures of  Uncaria  and  Tabebuia  extracts are potentially chemopreventive in CBA/Ca mice: a long‐term experiment | Zendy

Budán Ferenc | Zendy; Szabó István | Zendy; Varjas Tímea | Zendy; Nowrasteh Ghodratollah | Zendy; Dávid Tamás | Zendy; Gergely Péter | Zendy; Varga Zsuzsa | Zendy; Molnár Kornélia | Zendy; Kádár Balázs | Zendy; Orsós Zsuzsa | Zendy; Kiss István | Zendy; Ember István | Zendy

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Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long‐term experiment

Author(s) -

Budán Ferenc,

Szabó István,

Varjas Tímea,

Nowrasteh Ghodratollah,

Dávid Tamás,

Gergely Péter,

Varga Zsuzsa,

Molnár Kornélia,

Kádár Balázs,

Orsós Zsuzsa,

Kiss István,

Ember István

Publication year - 2011

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3281

Subject(s) - traditional medicine , term (time) , chemistry , medicine , physics , quantum mechanics

A long‐term experimental animal model was developed by our research group for the evaluation of potential chemopreventive effects. The inhibitory effects of agents on carcinogen (7,12‐dimethylbenz[a]anthracene (DMBA) induced molecular epidemiological biomarkers, in this case the expression of key onco/suppressor genes were investigated. The expression pattern of c‐myc , Ha‐ras , Bcl‐2 , K‐ras protooncogene and p53 tumour suppressor gene were studied to elucidate early carcinogenic and potential chemopreventive effects. The consumption of so‐called Claw of Dragon tea (CoD™ tea) containing the bark of Uncaria guianensis , Cat's Claw (Uncaria sp. U. tomentosa ) and Palmer trumpet‐tree (Tabebuia sp. T. avellanedae ) was able to decrease the DMBA‐induced onco/suppressor gene overexpression in a short‐term animal experiment. In a following study CBA/Ca mice were treated with 20 mg/kg bw DMBA intraperitoneally (i.p.) and the expression patterns of onco/suppressor genes were examined at several time intervals. According to the examined gene expression patterns in this long‐term experiment the chemopreventive effect of CoD™ tea consumption could be confirmed. Copyright © 2010 John Wiley & Sons, Ltd.

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