Premium
Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long‐term experiment
Author(s) -
Budán Ferenc,
Szabó István,
Varjas Tímea,
Nowrasteh Ghodratollah,
Dávid Tamás,
Gergely Péter,
Varga Zsuzsa,
Molnár Kornélia,
Kádár Balázs,
Orsós Zsuzsa,
Kiss István,
Ember István
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3281
Subject(s) - dmba , carcinogen , 7,12 dimethylbenz[a]anthracene , biology , antimutagen , gene expression , suppressor , traditional medicine , anticarcinogen , gene , pharmacology , chemistry , biochemistry , carcinogenesis , medicine , mutagen
A long‐term experimental animal model was developed by our research group for the evaluation of potential chemopreventive effects. The inhibitory effects of agents on carcinogen (7,12‐dimethylbenz[a]anthracene (DMBA) induced molecular epidemiological biomarkers, in this case the expression of key onco/suppressor genes were investigated. The expression pattern of c‐myc , Ha‐ras , Bcl‐2 , K‐ras protooncogene and p53 tumour suppressor gene were studied to elucidate early carcinogenic and potential chemopreventive effects. The consumption of so‐called Claw of Dragon tea (CoD™ tea) containing the bark of Uncaria guianensis , Cat's Claw (Uncaria sp. U. tomentosa ) and Palmer trumpet‐tree (Tabebuia sp. T. avellanedae ) was able to decrease the DMBA‐induced onco/suppressor gene overexpression in a short‐term animal experiment. In a following study CBA/Ca mice were treated with 20 mg/kg bw DMBA intraperitoneally (i.p.) and the expression patterns of onco/suppressor genes were examined at several time intervals. According to the examined gene expression patterns in this long‐term experiment the chemopreventive effect of CoD™ tea consumption could be confirmed. Copyright © 2010 John Wiley & Sons, Ltd.