Forsythoside a inhibits the avian infectious bronchitis virus in cell culture | Zendy

Li Huawei | Zendy; Wu Jufu | Zendy; Zhang Zhongwen | Zendy; Ma Yuanyuan | Zendy; Liao Fangfang | Zendy; Zhang Yu | Zendy; Wu Guojuan | Zendy

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Forsythoside a inhibits the avian infectious bronchitis virus in cell culture

Author(s) -

Li Huawei,

Wu Jufu,

Zhang Zhongwen,

Ma Yuanyuan,

Liao Fangfang,

Zhang Yu,

Wu Guojuan

Publication year - 2011

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3260

Subject(s) - infectious bronchitis virus , virus , virology , cell culture , biology , in vitro , traditional medicine , microbiology and biotechnology , chemistry , medicine , biochemistry , genetics

Forsythoside A is a polyphenolic constituent of the fruits of Forsythia suspensa Vahl. which is widely used as an antiinflammatory agent in traditional Chinese medicine. In the present study, the effects of forsythoside A on cell infection by avian infectious bronchitis virus were assessed. A real‐time fluorescence quantitative PCR assay was used to determine mRNA content of IBV N gene. The pretreatment of cells with forsythoside A, adding forsythoside A post infection of cells, and treatment of virus with forsythoside A were analysed. The inhibitory effect of forsythoside A was confirmed by infecting primary chicken embryo kidney cells. Infected cells were inhibited by forsythoside A treatment. The data indicated that forsythoside A has the potential to prevent IBV infection in vitro. Copyright © 2010 John Wiley & Sons, Ltd.

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