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Preparation of novel apigenin‐enriched, liposomal and non‐liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy
Author(s) -
Arsić Ivana,
Tadić Vanja,
Vlaović Djordje,
Homšek Irena,
Vesić Sonja,
Isailović Gorana,
Vuleta Gordana
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3245
Subject(s) - liposome , medicine , apigenin , pharmacology , in vivo , chemistry , microbiology and biotechnology , biochemistry , biology , antioxidant , flavonoid
Two oil‐in‐water formulations, containing equal amounts of apigenin‐enriched chamomile flower extracts, for potential use as topical antiinflammatory agents, were prepared and their physicochemical properties evaluated. A pilot clinical study was then carried out to assess patient acceptability and efficacy. The creams were either non‐liposomal or liposomal. The liposomal formulations were more viscous, thus producing superior release characteristics in vitro . The clinical study also showed that the liposomal creams were, as antiinflammatory agents, slightly more effective in vivo than the non‐liposomal formulations. These results suggest that there is scope for the further development of even more effective and safer alternatives to corticosteroids. Copyright © 2010 John Wiley & Sons, Ltd.