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Antioxidant activity of yellow dock ( Rumex crispus L., Polygonaceae) fruit extract
Author(s) -
Maksimović Zoran,
Kovačević Nada,
Lakušić Branislava,
Ćebović Tatjana
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3234
Subject(s) - polygonaceae , rumex , botany , dock , biology , antioxidant , traditional medicine , polygonum , medicine , genetics , biochemistry
The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric‐reducing antioxidant power (FRAP), DPPH‐free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe 2+ /g; DPPH IC 50 : 3.7 μg/mL; LP IC 50 : 4.9 μg/mL), comparable to that of BHT (FRAP: 8.0 μg/mL; DPPH IC 50 : 19.4 μg/mL; LP IC 50 : 3.5 μg/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH‐Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl 4 ). Pretreatment with the R. crispus extract inhibited CCl 4 ‐induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright © 2010 John Wiley & Sons, Ltd.