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Radioprotective activity of Gentiana lutea extract and mangiferin
Author(s) -
Menkovic Nebojsa,
Juranic Zorica,
Stanojkovic Tatjana,
RaonicStevanovic Tatjana,
Šavikin Katarina,
Zdunić Gordana,
Borojevic Nenad
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3225
Subject(s) - mangiferin , pharmacology , in vitro , in vivo , cytotoxic t cell , chemistry , peripheral blood mononuclear cell , biology , traditional medicine , medicine , biochemistry , microbiology and biotechnology
Abstract Radioprotective/sensitizing actions of Gentiana lutea aqueous‐ethanol extract and mangiferin on radiation‐induced effects on different types of cells were investigated. The study focused on the decreasing survival of normal human immunocompetent cells, the survival of the malignant cells in vitro , and the survival of ex vivo irradiated cells before and after consumption of the extract by healthy volunteers. The in vitro experiments showed that mangiferin could inhibit cytotoxic action of ionizing irradiation (doses of 6 and 8 Gy) only on normal resting human PBMC, not stimulated for proliferation. Orally consumed G. lutea extract showed the potential to reduce the cytotoxic effect of x‐ray irradiation on normal human immunocompetent cells PBMC of some healthy people, without changing the susceptibility of malignant cells to be destroyed by irradiation. Since the radioprotective effect was individually dependent, further clinical studies are needed. Copyright © 2010 John Wiley & Sons, Ltd.