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Antiangiogenic phytochemicals and medicinal herbs
Author(s) -
Jeong SooJin,
Koh Wonil,
Lee EunOk,
Lee HyoJung,
Lee HyoJeong,
Bae Hyunsu,
Lü Junxuan,
Kim SungHoon
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3224
Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , pharmacology , stromal cell , traditional medicine , vegf receptors , kinase insert domain receptor , vascular endothelial growth factor a , bioinformatics , cancer research , biology
Medicinal herbs and their phytochemicals are potential novel leads for developing antiangiogenic drugs. This review aims to assess the current status of research with medicinal herbs and their phytochemicals for the development of antiangiogenic agents for cancer and other angiogenesis‐related diseases including inflammation, diabetic retinopathy, endometriosis and obesity. Most studies reviewed have focused on vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR‐2) signaling for endothelial response processes and have led to the identification of many potential antiangiogenic agents. Since human clinical trials with antiangiogenic modalities targeting VEGF/VEGFR‐2 signaling have shown limited efficacy and occasional toxic side effects, screening strategies for herbal phytochemicals based on other signaling pathways important for cancer‐endothelial and stromal crosstalks should be emphasized in the future. Copyright © 2010 John Wiley & Sons, Ltd.