Cryptolepine, isolated from  Sida acuta , sensitizes human gastric adenocarcinoma cells to TRAIL‐induced apoptosis | Zendy

Ahmed Firoj | Zendy; Toume Kazufumi | Zendy; Ohtsuki Takashi | Zendy; Rahman Mahmudur | Zendy; Sadhu Samir Kumar | Zendy; Ishibashi Masami | Zendy

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Cryptolepine, isolated from Sida acuta , sensitizes human gastric adenocarcinoma cells to TRAIL‐induced apoptosis

Author(s) -

Ahmed Firoj,

Toume Kazufumi,

Ohtsuki Takashi,

Rahman Mahmudur,

Sadhu Samir Kumar,

Ishibashi Masami

Publication year - 2011

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.3219

Subject(s) - apoptosis , pharmacognosy , sida , adenocarcinoma , human immunodeficiency virus (hiv) , virology , biology , medicine , traditional medicine , in vitro , viral disease , biological activity , cancer , biochemistry

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL‐resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μ m . Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL‐induced apoptosis at the aforementioned concentrations. Copyright © 2010 John Wiley & Sons, Ltd.

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