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Cryptolepine, isolated from Sida acuta , sensitizes human gastric adenocarcinoma cells to TRAIL‐induced apoptosis
Author(s) -
Ahmed Firoj,
Toume Kazufumi,
Ohtsuki Takashi,
Rahman Mahmudur,
Sadhu Samir Kumar,
Ishibashi Masami
Publication year - 2011
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3219
Subject(s) - apoptosis , pharmacognosy , sida , adenocarcinoma , human immunodeficiency virus (hiv) , virology , biology , medicine , traditional medicine , in vitro , viral disease , biological activity , cancer , biochemistry
Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL‐resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μ m . Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL‐induced apoptosis at the aforementioned concentrations. Copyright © 2010 John Wiley & Sons, Ltd.