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Zingiber officinale (ginger) compounds have tetracycline‐resistance modifying effects against clinical extensively drug‐resistant Acinetobacter baumannii
Author(s) -
Wang HuiMin,
Chen ChungYi,
Chen HsiAn,
Huang WanChun,
Lin WeiRu,
Chen TunChieh,
Lin ChunYu,
Chien HsinJu,
Lu PoLiang,
Lin ChiuMei,
Chen YenHsu
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3201
Subject(s) - zingiber officinale , antimicrobial , acinetobacter baumannii , zingiberaceae , dpph , tetracycline , antioxidant , traditional medicine , rhizome , drug resistance , microbiology and biotechnology , biology , chemistry , medicine , antibiotics , bacteria , biochemistry , genetics , pseudomonas aeruginosa
Extensively drug‐resistant Acinetobacter baumannii (XDRAB) is a growing and serious nosocomial infection worldwide, such that developing new agents against it is critical. The antimicrobial activities of the rhizomes from Zingiber officinale , known as ginger, have not been proven in clinical bacterial isolates with extensive drug‐resistance. This study aimed to investigate the effects of four known components of ginger, [6]‐dehydrogingerdione, [10]‐gingerol, [6]‐shogaol and [6]‐gingerol, against clinical XDRAB. All these compounds showed antibacterial effects against XDRAB. Combined with tetracycline, they showed good resistance modifying effects to modulate tetracycline resistance. Using the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging method, these four ginger compounds demonstrated antioxidant properties, which were inhibited by MnO 2 , an oxidant without antibacterial effects. After the antioxidant property was blocked, their antimicrobial effects were abolished significantly. These results indicate that ginger compounds have antioxidant effects that partially contribute to their antimicrobial activity and are candidates for use in the treatment of infections with XDRAB. Copyright © 2010 John Wiley & Sons, Ltd.