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Pharmacodynamic action of a commercial preparation of the mushroom Coprinus comatus in rats
Author(s) -
Sabo A.,
Stilinovic N.,
Vukmirovic S.,
Bukumiric Z.,
Capo I.,
Jakovljevic V.
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3182
Subject(s) - mushroom , medicine , pharmacodynamics , alloxan , body weight , antipyretic , traditional medicine , pharmacology , endocrinology , diabetes mellitus , chemistry , food science , pharmacokinetics , analgesic
The pharmacodynamic effect of a 7‐day oral treatment with a suspension of Coprinus comatus at doses of 0.835 and 1.670 g/kg in rats was studied. Changes in body weight, bile secretion and hypoglycaemic action were examined together with antipyretic activity and paw oedema tests. Such treatments resulted in a significantly lower increase in the body weight of tested animals (15.73 ± 8.36 g/rat in the untreated group, 8.44 ± 8.23 g/rat ( p < 0.05) and 3.18 ± 7.93 g/rat ( p < 0.05), for C. comatus 0.835 and 1.67 g/kg, respectively). Hypoglycaemic action was evident only in the glucose load test (6.79 ± 0.61 to 9.70 ± 1.16 ( p < 0.05) in the untreated group and 6.47 ± 0.35 to 7.27 ± 0.76 for C. comatus 1.67 g/kg). Histological examination of pancreas cross‐sections suggested certain protective functions of the mushroom suspension in alloxan poisoning. In the antipyretic test, a significantly lower increase in body temperature was observed in the mushroom‐pretreated rats. In the paw oedema test, no decrease in oedema induced by formalin injection was observed following treatment with C. comatus . Copyright © 2010 John Wiley & Sons, Ltd.