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Traditional medicine Taeeumjowitangkagambang exerts antiobesity and hypolipidemic effects via antioxidant enzyme enhancement
Author(s) -
Park CheolHwan,
Jeong SooJin,
Lee HyoJeong,
Lee EunOk,
Bae Hyunsu,
Lee MinHo,
Kim SunHyung,
Jung HeeJae,
Ahn Kyoo Seok,
Kim SungHoon
Publication year - 2010
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.3179
Subject(s) - tbars , endocrinology , triglyceride , medicine , glutathione peroxidase , antioxidant , superoxide dismutase , chemistry , thiobarbituric acid , catalase , adipokine , adipocyte , cholesterol , lipid peroxidation , leptin , adipose tissue , biochemistry , obesity
Taeeumjowitangkagambang (ETJKB) is a traditional Korean medicine that has been clinically used for obesity with little mechanistic understanding. The present study investigated antiobesity and hypolipidemic effects of ETJKB in high fat diet fed rats as well as a 3T3‐L1 pre‐adipocyte differentiation model. ETJKB significantly inhibited the lipidogenesis in 3T3‐L1 adipocytes in a concentration‐dependent manner as well as reduced the cellular adipokine leptin level. Daily oral gavage of ETJKB to rats fed a high fat diet significantly attenuated body weight gain and abdominal and epididymal fat weights. ETJKB treatment also reduced the levels of total cholesterol, low density lipoprotein (LDL) and triglyceride as well as increased high density lipoprotein (HDL) in serum compared with the untreated control. Similarly, the ETJKB treatment decreased the levels of total lipid, triglyceride and cholesterol in liver tissue in high fat diet fed rats. Interestingly, ETJKB significantly increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) and catalase in liver tissue, while decreasing the hydroxyl radical, thiobarbituric acid reactive substances (TBARS), carbonyl concentration. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB. Copyright © 2010 John Wiley & Sons, Ltd.